Under the guidance of Academician Li Jieshou, he made a systematic research on severe acute pancreatitis and made an important breakthrough in the treatment. So far, nearly 3000 cases of severe acute pancreatitis have been treated, and the mortality rate has dropped from 20% in the past to less than 5% at this center with the most transferred patients and the best curative effect in China. The main academic contributions are as follows:
① Through a series of practical development, early enteral nutrition has become a practical technology, which has been widely used in China and promoted the transformation of nutrition model of severe pancreatitis. The relevant research has been cited by many international guidelines. ② Continuous high flow hemofiltration is used to control the early excessive inflammatory reaction of severe pancreatitis. The hypothesis of eliminating inflammatory mediators and controlling excessive inflammatory reaction through hemofiltration is put forward. Through animal experiments and clinical studies, continuous high flow hemofiltration can significantly remove IL-6 and other mediators, prolong animal survival, reduce inflammatory reaction of patients and improve organ function. This technology has been widely used at present Application. ③ Improvement of operation and drainage methods for severe pancreatitis: traditional necrotic clearance is prone to bleeding. And postoperative drainage effect is not good, infection is difficult to control. We have made some improvements, such as limited removal of necrotic tissue, combined with postoperative continuous irrigation and drainage, to avoid bleeding and other complications caused by excessive removal, improve the drainage effect, and significantly reduce the incidence of postoperative complications. ④ Minimally invasive treatment of severe pancreatitis: on the basis of percutaneous puncture and drainage, we developed percutaneous negative pressure drainage and endoscope assisted necrotic tissue removal. About 70% of the patients avoided the operation and reduced the complications. Relevant studies were adopted by the Japanese guidelines for biliary pancreatitis (2010). ⑤ In the research field of nutritional metabolism of critically ill patients, the changes of energy metabolism, protein metabolism, glucose metabolism and vitamin metabolism in critically ill patients were systematically elucidated, and the mechanism of hypoalbuminemia in infected patients was elucidated.